Viruses Under Electron Microscope

Variety of colorized transmission electron micrographs showcasing different viruses, including HIV, SARS-CoV-2, and influenza A, highlighting their structure and characteristics.

Negatively-stained transmission electron micrograph of California encephalitis virus virion

Negatively-stained transmission electron micrograph of California encephalitis virus virion

This colorized transmission electron micrograph (TEM) depicts numbers of influenza A virions while in their late passage growth phase.

Human papilloma virus, HPV

This transmission electron microscope image shows SARS-CoV-2, the virus that causes COVID-19, isolated from a patient in the U.S. Virus particles are shown emerging from the surface of cells cultured in the lab. The spikes on the outer edge of the virus particles give coronaviruses their name, crown-like. Image captured and colorized at NIAID's Rocky Mountain Laboratories (RML) in Hamilton, Montana. Credit: NIAID.

Transmission electron micrograph of HIV-1 virus particles (colorized red/yellow) replicating from an HIV-infected H9 T-cell (blue).

Transmission electron micrograph of HIV-1 virus particles (colorized red/yellow) replicating from an HIV-infected H9 T-cell (blue).

Human papilloma virus (HPV). Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter around 55 nm.

Hepatitis A virus (picornavirus). HAV causes a hepatitis that is almost always benign. Image made from transmission electron microscopy. Approximate viral diameter: 30 nm.

Feline calicivirus. This electron micrograph reveals the morphologic traits exhibited by the feline calicivirus (FCV), a Caliciviridae family member. Feline calicivirus virions average 35nm - 40nm in diameter, and exhibit cup-like surface depressions, which sometimes manife

Transmission electron micrograph of a variant strain of SARS-CoV-2 virus particles (UK B.1.1.7), isolated from a patient sample and cultivated in cell culture. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland.

This colorized negative-stained transmission electron micrograph (TEM) depicts the ultrastructural details of a number of influenza virus particles, or virions. A member of the taxonomic family Orthomyxoviridae, the influenza virus is a single-stranded RNA organism. The flu is a contagious respiratory illness caused by influenza viruses. It can cause mild to severe illness, and at times can lead to death. The best way to prevent this illness is by getting a flu vaccination each fall.

This colorized negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among swine throughout the year, but most outbreaks occur during the late fall and winter months similar to outbreaks in humans. The classical swine flu virus (an influenza type A H1N1 virus) was first isolated from a pig in 1930.

Influenza virus. Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter ranges from around 80 to 120 nm.

Influenza virus of the Orthomyxoviridae family (respiratory viral infection). Transmission electron microscopy, viral diameter 80 to 120 nanometers.

This digitally-colorized transmission electron micrograph (TEM) revealed the presence of hepatitis B virions. The large round virions are known as Dane particles.

HPV (human papillomavirus). The human papillomavirus or HPV is the cause of sexually transmitted infections (genital warts that can induce cancer of the cervix). HPV is also the cause of skin warts. View taken from an electron microscope transmission. Viral diameter approximately 55 nm.

HPV (Human papillomavirusvirus). The human papillomavirus or papillomavirus is the cause of sexually transmitted infections (condyloma acuminata which can induce cancer of the cervix). They are also the cause of skin infections: warts. View produced from a transmission electron microscopy image. Viral diameter approximately: 55 nm.

This preliminary negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among swine throughout the year, but most outbreaks occur during the late fall an

Norwalk virus. Electron micrograph of the Norwalk virus, an RNA virus the genus Norovirus (caliciviridae) responsable for gastroenteritis.

Influenza virus. Image produced from an image taken with transmission electron microscopy. Viral diameter ranges from around 80 to 120 nm.

Staphyloccus aureus. Bacteria responsible for food poisoning, localized suppurative infections and some cases of septicemia. Seen under optical microscopy X 1000

Pneumococcus (streptococcus pneumoniae). Pneumococcus is the bacterium that causes pneumonia, bronchial pneumonia, purulent pleurisy, bacterial meningitis, ear infections, sinusitis and conjunctivitis. Optical microscopy x 2000.

Transmission electron micrograph of cytomegalovirus (CMV) particles (pink) found within intracellular vesicles of an infected macrophage (green).

Hepatitis A virus (HAV). Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter ranges from around 20 to 30 nm.

Coronavirus. Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter ranges from around 80 to 160 nm.

Hepatitis B virus (Hepadnavirid family). HBV causes sexually transmitted or blood-borne hepatitis. Cirrhosis occurs in 20% of cases 15 to 20 years after the onset of infection. Image made from transmission electron microscopy. Approximate viral diameter: 22 nm.

Negatively-stained transmission electron micrograph of numerous herpes simplex virions, members of the Herpesviridae virus family

Influenza virus. Viruses of the Orthomyxoviridae family. Avian plague virus. The flu virus is the cause of an infectious and contagious respiratory disease. It evolves into a major pandemic interspersed with small localized seasonal epidemics. Virus diameter: about 100 nm. Computer graphics on transmission electron microscope view

Poliovirus. Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter ranges from around 27 to 30 nm.

This colorized transmission electron micrograph (TEM) depicts numbers of influenza A virions while in their late passage growth phase.

HSV: Herpes virus. HSV is the cause of cold sores, genital herpes, chickenpox, infectious mononucleosis, roseola, sometimes shingles. they are involved in certain cancers, including Burkitt's lymphoma. View produced from a transmission electron microscopy image. Viral diameter approximately: 200 nm.

Streptococcus pneumoniae. Color enhanced Transmission electron micrograph (TEM) of type 4 Streptococcus pneumoniae bacteria adherent to a pharyngeal epithelial cell. This Gram-negative bacterium is a leading cause of pneumonia. It also causes many other pathologies like middle ear infections (otitis media), bacteremia and meningitis.

1981 Dr. Erskine Palmer This transmission electron micrograph (TEM) revealed the presence of hepatitis B virions. The large round virions are known as Dane particles. Hepatitis means inflammation of the liver. Toxins, certain drugs, some diseases, heavy alcohol use, and bacterial and viral infections can all cause hepatitis. Hepatitis is also the name of a family of viral infections that affect the liver the most common types are hepatitis A, hepatitis B, and hepatitis C.

Virus used for the preparation of smallpox vaccine. An electron micrograph of a Vaccinia virus. Vaccinia virus is normally confined to cattle, but is conveyed to humans through vaccination, thereby, imparting immunity to the smallpox virus. See image n1312605 on the site.

Epstein-Barr virus (human herpesvirus 4, HHV-4). It causes infectious mononucleosis and Burkitt's lymphoma. View taken with HDRI image processing from a transmission electron microscopy image. Viral diameter about 200 nm.

Influenza virus (Myxovirus influenzae) from the Orthomyxoviridae family. Viral diameter from 80 to 120 nanometers, taken using transmission electron microscopy.

Hepatitis D virus (HDV). Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter around 35 nm.

HPV (human papillomavirus). The human papillomavirus or HPV is the cause of sexually transmitted infections (genital warts that can induce cancer of the cervix). HPV is also the cause of skin warts. View taken from an electron microscope transmission. Viral diameter approximately 55 nm.

Human Papillomavirus. Colored transmission electron micrograph (TEM) of human papillomavirus (HPV). The HPV is involved in the development of cervical cancers.

HSV: Herpes virus. HSV is the cause of cold sores, genital herpes, chickenpox, infectious mononucleosis, roseola, sometimes shingles. they are involved in certain cancers, including Burkitt's lymphoma. View produced from a transmission electron microscopy image. Viral diameter approximately: 200 nm.

2009 C. S. Goldsmith and A. Balish This preliminary negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. See PHIL 11213 for a black and white version of this image. What is Swine Influenza Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death r

Colorized transmission electron micrograph of monkeypox particles (orange) found within an infected cell (brown), cultured in the laboratory.

This colorized negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among swine throughout the year, but most outbreaks occur during the late fall and winter months similar to outbreaks in humans. The classical swine flu virus (an influenza type A H1N1 virus) was first isolated from a pig in 1930.

La Crosse virus. Electron micrograph of the La Crosse virus (LCV), a RNA Bunyaviridus responsible for La Crosse encephalitis.

Flavivirus (family Flaviviridae), these viruses are responsible for yellow fever, dengue fever, Japanese encephalitis, Zika virus, West Nile encephalitis. They are transmitted by mosquitoes or ticks. image produced from transmission electron microscopy (viral diameter approximately 40 to 60 nm).

Influenza virus. Viruses of the Orthomyxoviridae family. Avian plague virus. The flu virus is the cause of an infectious and contagious respiratory disease. It evolves into a major pandemic interspersed with small localized seasonal epidemics. Virus diameter: about 100 nm. Computer graphics on transmission electron microscope view.

Colorized transmission electron micrograph of monkeypox virus particles (blue) cultivated and purified from cell culture.

Influenza A virus causes flu in humans, swine, birds, horses and dogs. Which species the virus will infect is determined by the glycoprotein spikes on its outer envelope. They are many strains of influenza A virus, among which the avian flu virus (H5N1), swine flu (H1N1) or human. Transmission Electron Micrograph (TEM).

Rotavirus. Color enhanced transmission electron micrograph (TEM) of Rotavirus, a type of RNA virus (Reoviridae) responsible for the winter pediatric gastroenteritis.

Fluvirus - Influenza virus or Influenza virus. The influenza virus causes the seasonal flu, with in humans, a set of symptoms associating: fever, headache, cough, pharyngitis, myalgia, asthenia and anorexia. View produced from a transmission electron microscopy view. Viral diameter approximately: 80 to 120 nm.

This colorized transmission electron micrograph (TEM) depicts numbers of influenza A virions while in their late passage growth phase.

Colorized transmission electron micrograph of monkeypox particles (orange) found within an infected cell (brown), cultured in the laboratory

Negatively-stained transmission electron micrograph of Hong Kong flu virus virions

Hepatitis A virus (picornavirus). The HAV. almost always causes mild hepatitis. View produced from a transmission electron microscopy image. Viral diameter approximately: 30 nm.

Swine flu virus seen at the MET. False color transmission electron micrograph (TEM) of the Swine Fever virus. Under a plate magnification of 37,800X, this colorized transmission electron micrograph (TEM) depicted the A/New Jersey/76 (Hsw1N1) virus, while in the virus' first developmental passage through a chicken egg. Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza that regularly cause outbreaks of influenza among pigs. Swine flu viruses cause high levels of illness and low death rates among pigs. Swine influenza viruses may circulate in swine throughout the year, but most outbreaks among swine herds occur during the late fall and winter months similar to humans. The classical swine flu virus (an influenza type A H1N1 virus) was first isolated from a pig in 1930. Swine flu viruses do not normally infect humans. However, sporadic human infections with swine flu have occurred. In the past several years, on average CDC has received about one influen

Colorized transmission electron micrograph of rabies virus particles (green).

Coronavirus (CoV). viruses of the Coronaviridae family and the Orthocoronavirinae subfamily. It is a pathogen of respiratory syndromes. Viewed from a transmission electron microscopy (TEM) image. Viral diameter 80nm to 100nm.

HPV (human papillomavirus). The human papillomavirus or HPV is the cause of sexually transmitted infections (genital warts that can induce cancer of the cervix). HPV is also the cause of skin warts. View taken from an electron microscope transmission. Viral diameter approximately 55 nm.

Rotavirus. Image produced from an image taken with transmission electron microscopy. Viral diameter around 60 to 80 nm.

Hepatitis A virus (HAV). Image produced using high-dynamic-range imaging (HDRI) from an image taken with transmission electron microscopy. Viral diameter ranges from around 20 to 30 nm.

Influenza virus of the Orthomyxoviridae family (respiratory viral infection). Transmission electron microscopy, viral diameter 80 to 120 nanometers.

Coronavirus (CoV). viruses of the Coronaviridae family and the Orthocoronavirinae subfamily. It is a pathogen of respiratory syndromes. Viewed from a transmission electron microscopy (TEM) image. Viral diameter 80nm to 100nm.

This negatively-stained transmission electron micrograph (TEM) revealed ultrastructural morphology of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which was formerly known as novel coronavirus. (MERS-CoV) was identified in 2012 as the cause of respiratory illness in people. Investigations are being done to figure out the source of MERS-CoV and how it spreads. So far, there are no reports of anyone in the US getting infected with MERS-CoV. Most people who got infected with MERS-CoV developed severe acute respiratory illness with symptoms of fever, cough, and shortness of breath. About half of them died. Some people were reported as having a mild respiratory illness. MERS-CoV has been shown to spread between people who are in close contact. Transmission from infected patients to healthcare personnel has also been observed. Clusters of cases in Saudi Arabia, Jordan, the UK, France, Tunisia, and Italy are being investigated.

Fluvirus - Influenza virus or Influenza virus. The influenza virus causes the seasonal flu, with in humans, a set of symptoms associating: fever, headache, cough, pharyngitis, myalgia, asthenia and anorexia. View produced from a transmission electron microscopy view. Viral diameter approximately: 80 to 120 nm.

Swine flu virus

Colorized transmission electron micrograph of two HIV-1 virus particles (red/yellow) budding from the plasma membrane of an H9 T cell (teal). 2024 : Long-Acting HIV Treatment Benefits Adults with Barriers to Daily Pill Taking and Adolescents with Suppressed HIV.

Adenovirus (highly contagious virus), responsible for: Colds, pharyngitis, bronchitis, pneumonia, gastroenteritis, conjunctivitis and keratitis. Image made from a transmission electron microscopy view.

Yellow Fever Virus. Color enhanced transmission electron micrograph (TEM) of Yellow Fever Viruses, transmitted to man by Aedes aegypti mosquito bite.

This thin-section transmission electron micrograph (TEM) revealed the ultrastructural appearance of a single virus particle, or virion, of measles virus. The measles virus is a paramyxovirus, of the genus Morbillivirus. It is 100-200 nm in diameter, with a core of single-stranded RNA, and is closely related to the Rinderpest and canine distemper viruses. Two membrane envelope proteins are important in pathogenesis. They are the F (fusion) protein, which is responsible for fusion of virus and host cell membranes, viral penetration, and hemolysis, and the H (hemagglutinin) protein, which is responsible for adsorption of virus to cells. There is only one antigenic type of measles virus. Although studies have documented changes in the H glycoprotein, these changes do not appear to be epidemiologically important (ie no change in vaccine efficacy has been observed).

HPV (human papillomavirus). The human papillomavirus or HPV is the cause of sexually transmitted infections (genital warts that can induce cancer of the cervix). HPV is also the cause of skin warts. View taken from an electron microscope transmission. Viral diameter approximately 55 nm.

This transmission electron microscope image shows SARS-CoV-2, the virus that causes COVID-19, isolated from a patient in the U.S. Virus particles are shown emerging from the surface of cells cultured in the lab. The spikes on the outer edge of the virus particles give coronaviruses their name, crown-like. Image captured and colorized at NIAID's Rocky Mountain Laboratories (RML) in Hamilton, Montana. Credit: NIAID

Influenza A virus causes flu in humans, swine, birds, horses and dogs. Which species the virus will infect is determined by the glycoprotein spikes on its outer envelope. They are many strains of influenza A virus, among which the avian flu virus (H5N1), swine flu (H1N1) or human. Transmission Electron Micrograph (TEM).

This transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by norovirus virions, or virus particles. Noroviruses belong to the genus Norovirus, and the family Caliciviridae. They are a group of related, single-stranded RNA, nonenveloped viruses that cause acute gastroenteritis in humans. Norovirus was recently approved as the official genus name for the group of viruses provisionally described as Norwalk-like viruses (NLV).

HIV virus. Image produced from an image taken with transmission electron microscopy. Viral diameter around 110 to 125 nm.

Electron micrograph of the West Nile virus. West Nile virus is a flavivirus commonly found in Africa, West Asia, and the Middle East. It is closely related to St. Louis encephalitis virus found in the United States

AIDS virus. TEM (Transmission Electron Microscope)

This negatively-stained transmission electron micrograph (TEM) captured some of the ultrastructural details exhibited by the new influenza A (H7N9) virus. On April 1, 2013, the World Health Organization (WHO) first reported 3 human infections with a new influenza A (H7N9) virus in China. Since then, additional cases have been reported. Most reported cases have severe respiratory illness and, in some cases, have died. At this time, no cases of H7N9 outside of China have been reported. The new H7N9 virus has not been detected in people or birds in the United States. This new H7N9 virus is an avian (bird) influenza (flu) virus. Human infections with avian influenza (AI, or bird flu) are rare but have occurred in the past, most commonly after exposure to infected poultry. However, this is the first time that this bird flu subtype (H7N9) has been found in people. This virus is very different from other H7N9 viruses previously found in birds.

Smallpox virus. Transmission Electron Micrograph (TEM) of smallpox viruses.

This transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by norovirus virions, or virus particles. Noroviruses belong to the genus Norovirus, and the family Caliciviridae. They are a group of related, single-stranded RNA, nonenveloped viruses that cause acute gastroenteritis in humans. Norovirus was recently approved as the official genus name for the group of viruses provisionally described as Norwalk-like viruses (NLV).

This electron micrograph depicts hepatitis E viruses (HEV), provisionally classified as members of the Caliciviridae family. Hepatitis E virus HEV the major etiologic agent of enterically transmitted non A non B hepatitis worldwide, is a spherical, non

HPV (Human papillomavirusvirus). The human papillomavirus or papillomavirus is the cause of sexually transmitted infections (condyloma acuminata which can induce cancer of the cervix). They are also the cause of skin infections: warts. View produced from a transmission electron microscopy image. Viral diameter approximately: 55 nm.

Rubella virus (rubivirus from the Togaviridae family). Image taken with transmission electron microscopy, (viral diameter around 50 to 70 nm).

Coronavirus (CoV). viruses of the Coronaviridae family and the Orthocoronavirinae subfamily. It is a pathogen of respiratory syndromes. Viewed from a transmission electron microscopy (TEM) image. Viral diameter 80nm to 100nm.

Negatively stained electron micrograph of Parvovirus H-1 virions of the Parvoviridae family of DNA viruses

Swine flu virus. Negative stained transmission electron micrograph. Photo by C. S. Goldsmith and A. Balish, 2009.

This electron microscopic (EM) image depicts monkeypox virus particles, obtained from a clinical specimen associated with the 2003 prairie dog outbreak. This is a thin section image of a specimen of human skin. On the left are oval-shaped mature virus particles, and on the right crescents and spherical particles of immature virions.

This digitally-colorized transmission electron micrograph (TEM) revealed the presence of hepatitis B virions. The large round virions are known as Dane particles.

Herpes simplex virus. Electron micrograph of the Herpes simplex virus.

Colorized TEM image of human white blood cells

This transmission electron microscope image shows SARS-CoV-2 also known as 2019-nCoV, the virus that causes COVID-19. Virus particles emerge from the surface of a cell cultured in the laboratory. Spikes on the outer edge of virus particles give coronaviruses their name, shaped like a crown. Image captured and colorized at Rocky Mountain Laboratories in Hamilton, Montana. Credit: NIAID

The human coronavirus causes respiratory infections (colds), and gastroenteritis. Image made from a transmission electron microscopy view. Approximate viral diameter: 80 to 160 nm.

Coronavirus (CoV). viruses of the Coronaviridae family and the Orthocoronavirinae subfamily. It is a pathogen of respiratory syndromes. Viewed from a transmission electron microscopy (TEM) image. Viral diameter 80nm to 100nm.

This colorized negative stained transmission electron micrograph (TEM) depicted some of the ultrastructural morphology of the A/CA/4/09 swine flu virus. Swine Influenza (swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Swine flu viruses cause high levels of illness and low death rates in pigs. Swine influenza viruses may circulate among swine throughout the year, but most outbreaks occur during the late fall and winter months similar to outbreaks in humans. The classical swine flu virus (an influenza type A H1N1 virus) was first isolated from a pig in 1930.

Adenovirus (highly contagious virus causing lymphadenopathy symptomatizing swelling of the glands in the neck, accompanied by a cold, or pharyngitis, or bronchitis, sometimes also conjunctivitis, keratitis, or a combination of the two (keratoconjunctivitis). View produced from a transmission electron microscopy view Viral diameter approximately: 80 to 110 nm.

Rotavirus. Color enhanced transmission electron micrograph (TEM) of Rotavirus, a type of RNA virus (Reoviridae) responsible for the winter pediatric gastroenteritis.

Colorized transmission electron micrograph of mpox virus particles (pink) found within an infected cell (yellow), cultured in the laboratory.

Cytomegalovirus (human herpesvirus 5, HHV-5). It causes a dangerous mononucleosis syndrome especially in the immunocompromised. View taken with HDRI image processing from a transmission electron microscopy image. Viral diameter about 200 nm.

Monkeypox virus particles, illustration

Pneumococcus (streptococcus pneumoniae). Pneumococcus is the bacterium that causes pneumonia, bronchial pneumonia, purulent pleurisy, bacterial meningitis, ear infections, sinusitis and conjunctivitis. Optical microscopy x 1000.

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