Fishing net buoys piled on a dock. Key West is a city and an island of the same name near the southernmost tip of the Florida Keys in Monroe County, Florida, United States. Key West is known as the Southernmost City in the Continental United States. It is also the southern terminus of U.S. Route 1, State Road A1A. Key West is 129 miles southwest of Miami, Florida, and 106 miles north northeast of Havana, Cuba, Key West is a seaport destination for many passenger cruise ships. The central busines