Cerebrovascular accident and antithrombotics. Top left, the brain in frontal section with its vascularization. A zoom of a cross-sectional vessel from the brain to detail the coagulation cascade in the formation of a clot or thrombus (lower right). In the liver (top right) Inactive vitamin K (yellow beads) become active (yellow stars) thanks to epoxide-reductase. Active vitamin K will activate coagulation factors which will, in turn, trigger the coagulation cascade in the blood vessel. In yellow on the left wall of the vessel, an atheroma plaque will release tissue factor (VII). Below, to the left of the clot, a platelet (white) in the aggregation phase.