Calcitonin peptide bound to its receptor, animation. The calcitonin gene-related peptide (CGRP, orange) binds to its receptor (blue) on the membranes of neurons and smooth muscle cells in cerebral (brain) blood vessels. This activates a signal cascade through G-proteins (glowing blue, lower centre) that leads to a dilatation of brain blood vessels (vasodilatation). This is a factor in disorders such as migraines, and blocking this receptor is a potential treatment for migraines.
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Image Number: 4128-V58566676Royalty FreeCredit Line:JUAN GAERTNER/SCIENCE PHOTO LIBRARY/SuperStockCollection:Science Photo Library Contributor:JUAN GAERTNER/SCIENCE PHOTO LIBRARY Model Release:NoProperty Release:NoDuration:0:00:07Frame Rate:25 FPSResolution:1920×1080