HEADACHE, ARTWORK. HEADACHE, ARTWORK Migraine. Illustration of a migraine theory explaining its onset as being triggered by a malfunction in the synchronization of sensory input which causes pain through stimulation of the trigemial nerve and inflammation from leakage in the blood vessels of the dura mater. The triptan family of drugs seems to affect migraines on three different levels. First, they may trigger the vasoconstriction of the blood vessels in the dura mater, reducing leakage. T
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