This scanning electron micrograph (SEM) revealed some of the ultrastructural morphology displayed by red blood cells (RBCs) in a blood specimen of a 6 year old male patient with sickle cell anemia, which was accompanied by hereditary persistence of fetal hemoglobin (HPFH). In these individuals, the presence of the persistent fetal hemoglogin reduces the severity of the consequences of the sickle cell disease, thereby, reducing the degree of cellular deformity, i.e., sickling, seen in the sickled