Welcome Sign Above Virginia Street. ca. 1949, Reno, Nevada, USA, Virginia Street at Night, Reno, Nevada. RENO-the largest city in Nevada is ideally situated in fertile meadows, on the banks of the Truckee River, and surrounded by the majestic Sierra Nevada Mountains. The abundant beauties and attractions of this cosmopolitan city, its zestful and sparkling life, justifies the claim to 'The Biggest Little City in the World.'